A statistical approach for evaluating the effectiveness of heartworm preventive drugs: what does 100% efficacy really mean?

Abstract Background Initial studies of heartworm preventive drugs all yielded an observed efficacy of 100% with a single dose, and based on these data the US Food and Drug Administration (FDA) required all products to meet this standard for approval.Those initial studies, however, were based on just a few strains of parasites, and therefore were no

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Failure to identify an acute exercise effect on executive function assessed by the Wisconsin Card Sorting Test

Purpose: Acute exercise has been linked to the facilitation of executive function, but little is known regarding executive function assessed by the Wisconsin Card Sorting Test (WCST).The present research consisted of two experiments aimed to determine whether acute aerobic exercise influences successive WCST performance.Methods: In Study 1, 27 youn

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